Passing the Baton: Substrate Channeling in Mammalian Base Excision Repair Pathways
نویسندگان
چکیده
Rajendra Prasad, David D. Shock, William A. Beard, and Samuel H. Wilson Laboratory of Structural Biology, National Institutes of Health, NIEHS, 111 T.W. Alexander Drive, PO Box 12233, MD F3-01, Research Triangle Park, North Carolina 27709, USA Running head: Substrate channeling in mammalian BER pathways Address correspondence to: Samuel H. Wilson, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA. Tel: 919-541-4701; Fax: 919-541-3592; E-mail [email protected]
منابع مشابه
Pol β associated complex and base excision repair factors in mouse fibroblasts
During mammalian base excision repair (BER) of lesion-containing DNA, it is proposed that toxic strand-break intermediates generated throughout the pathway are sequestered and passed from one step to the next until repair is complete. This stepwise process is termed substrate channeling. A working model evaluated here is that a complex of BER factors may facilitate the BER process. FLAG-tagged ...
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